DANTRIUM® Intravenous (dantrolene sodium for injection)
Malignant hyperthermia (MH), an event triggered in susceptible individuals by various anesthetics, strikes fast and without warning,
and is a sudden and life threatening condition. The Malignant Hyperthermia Association of the United States (MHAUS) recommends a
minimum stocking level of 36 vials of Dantrium Intravenous (dantrolene sodium for injection) for facilities that use triggering
agents. This number is based on the amount of Dantrium I.V. used to treat an MH episode for the average adult (70 kg). However, the
size of the patient and the severity of the reaction will dictate the number of vials needed. If you would like to order educational
materials on how to prepare your facility for an MH crisis, please contact MHAUS at 800-98-MHAUS.
Dantrium Intravenous is indicated for the management of fulminant hypermetabolism of skeletal muscle characteristic of malignant
hyperthermia crises in patients of all ages when given in conjunction with supportive therapy. Dantrium I.V. is also indicated
preoperatively, and sometimes postoperatively to prevent or attenuate the development of clinical and laboratory signs of malignant
hyperthermia in individuals judged to be malignant hyperthermia susceptible.
Management of an MH crisis requires various supportive measures individualized for the patient's condition. Administration of Dantrium
I.V. is one component of therapy and should not be considered a substitute for these measures. Even when properly treated, an MH
crisis can result in death. Adverse events with Dantrium I.V. include loss of grip strength, weakness, drowsiness, dizziness and
thrombophlebitis. There have been rare reports of pulmonary edema. For post MH crisis follow-up, please see Dosage and Administration
section of the prescribing information.
For technical information on Dantrium IV, please contact Medical Communications at 1-800-836-0658.
Dantrium IV is the brand of dantrolene sodium for injection available in the US and Canada. Please contact customer service in the US at 1-800-448-4878 or in Canada at 1-800-265-8676. Click here for a picture of the US/Canada presentation.
Dantrolen IV is the brand of dantrolene sodium for injection available from Germany for countries outside of the US and Canada. Please contact customer service in Germany for ordering information via fax: +49-6151-877-599.Click here for a picture of the German presentation.
Dantrium I.V. Full Prescribing Product Information (PDF Format).
Can't view the PDF? Click here to download Adobe Acrobat.
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